Gene information
Official symbol CETP
Official full name cholesteryl ester transfer protein
Gene type protein-coding gene
Chromosome16q13
Alias symbolBPIFF
Gene familyBPI fold containing
Resources
Entrez Gene 1071
HGNC HGNC:1869
Ensembl ENSG00000087237
Vega OTTHUMG00000133279
UCSC uc002eki.3
GO terms: 68 records
GO Description Category LogP Number of genes Detail
GO:0005319 lipid transporter activity GO Molecular Functions -5.47143795 11 More
GO:0005496 steroid binding GO Molecular Functions -8.57765300 12 More
GO:0005543 phospholipid binding GO Molecular Functions -6.61792344 45 More
GO:0005548 phospholipid transporter activity GO Molecular Functions -2.19985109 4 More
GO:0006066 alcohol metabolic process GO Biological Processes -16.7128396 29 More
GO:0006638 neutral lipid metabolic process GO Biological Processes -9.91206723 13 More
GO:0006639 acylglycerol metabolic process GO Biological Processes -9.97063695 13 More
GO:0006641 triglyceride metabolic process GO Biological Processes -9.32996784 11 More
GO:0006644 phospholipid metabolic process GO Biological Processes -2.96272379 13 More
GO:0006650 glycerophospholipid metabolic process GO Biological Processes -2.76007072 11 More
GO:0006869 lipid transport GO Biological Processes -16.6388990 29 More
GO:0008202 steroid metabolic process GO Biological Processes -19.3229835 29 More
GO:0008203 cholesterol metabolic process GO Biological Processes -19.4799126 22 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0010743 regulation of macrophage derived foam cell differentiation GO Biological Processes -20.3455172 15 More
GO:0010745 negative regulation of macrophage derived foam cell differentiation GO Biological Processes -12.3554756 8 More
GO:0010874 regulation of cholesterol efflux GO Biological Processes -13.5117096 13 More
GO:0010876 lipid localization GO Biological Processes -20.1994935 34 More
GO:0015248 sterol transporter activity GO Molecular Functions -5.41560423 6 More
GO:0015485 cholesterol binding GO Molecular Functions -6.09984616 12 More
GO:0015748 organophosphate ester transport GO Biological Processes -5.98331847 11 More
GO:0015850 organic hydroxy compound transport GO Biological Processes -17.9399475 23 More
GO:0015914 phospholipid transport GO Biological Processes -7.60367088 11 More
GO:0015918 sterol transport GO Biological Processes -16.3959877 17 More
GO:0016125 sterol metabolic process GO Biological Processes -19.5624674 23 More
GO:0030301 cholesterol transport GO Biological Processes -18.3843949 17 More
GO:0031210 phosphatidylcholine binding GO Molecular Functions -5.56986570 6 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032370 positive regulation of lipid transport GO Biological Processes -15.5410017 17 More
GO:0032371 regulation of sterol transport GO Biological Processes -19.2332049 29 More
GO:0032373 positive regulation of sterol transport GO Biological Processes -13.7255371 12 More
GO:0032374 regulation of cholesterol transport GO Biological Processes -19.2332049 29 More
GO:0032376 positive regulation of cholesterol transport GO Biological Processes -13.7255371 12 More
GO:0032934 sterol binding GO Molecular Functions -5.20663428 12 More
GO:0032994 protein-lipid complex GO Cellular Components -17.0133835 14 More
GO:0034358 plasma lipoprotein particle GO Cellular Components -17.5986271 14 More
GO:0034364 high-density lipoprotein particle GO Cellular Components -15.5094832 12 More
GO:0034367 protein-containing complex remodeling GO Biological Processes -22.5554593 16 More
GO:0034368 protein-lipid complex remodeling GO Biological Processes -23.1924108 16 More
GO:0034369 plasma lipoprotein particle remodeling GO Biological Processes -23.1924108 16 More
GO:0034370 triglyceride-rich lipoprotein particle remodeling GO Biological Processes -9.26986898 6 More
GO:0034372 very-low-density lipoprotein particle remodeling GO Biological Processes -9.66344956 6 More
GO:0034374 low-density lipoprotein particle remodeling GO Biological Processes -13.3517229 9 More
GO:0034375 high-density lipoprotein particle remodeling GO Biological Processes -13.3517229 9 More
GO:0042632 cholesterol homeostasis GO Biological Processes -21.5492593 34 More
GO:0043178 alcohol binding GO Molecular Functions -5.93737043 9 More
GO:0043691 reverse cholesterol transport GO Biological Processes -17.1886584 11 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0046470 phosphatidylcholine metabolic process GO Biological Processes -5.57583811 8 More
GO:0046486 glycerolipid metabolic process GO Biological Processes -5.86759713 18 More
GO:0050997 quaternary ammonium group binding GO Molecular Functions -4.83197184 6 More
GO:0055088 lipid homeostasis GO Biological Processes -20.8046481 43 More
GO:0055090 acylglycerol homeostasis GO Biological Processes -12.4730141 17 More
GO:0055091 phospholipid homeostasis GO Biological Processes -6.04894404 5 More
GO:0055092 sterol homeostasis GO Biological Processes -21.3864243 34 More
GO:0070328 triglyceride homeostasis GO Biological Processes -12.4730141 17 More
GO:0071825 protein-lipid complex subunit organization GO Biological Processes -20.9970896 17 More
GO:0071827 plasma lipoprotein particle organization GO Biological Processes -21.6197515 17 More
GO:0097006 regulation of plasma lipoprotein particle levels GO Biological Processes -27.6960426 22 More
GO:0120009 intermembrane lipid transfer GO Biological Processes -4.61583694 6 More
GO:0120013 lipid transfer activity GO Molecular Functions -4.61583694 6 More
GO:0120015 sterol transfer activity GO Molecular Functions -6.64459385 6 More
GO:0120020 cholesterol transfer activity GO Molecular Functions -6.77152389 6 More
GO:1901615 organic hydroxy compound metabolic process GO Biological Processes -22.7091625 41 More
GO:1902652 secondary alcohol metabolic process GO Biological Processes -19.9585075 23 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1905954 positive regulation of lipid localization GO Biological Processes -22.7388039 24 More
GO:1990777 lipoprotein particle GO Cellular Components -17.5986271 14 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04979 Cholesterol metabolism KEGG Pathway -20.0696655 17 More
Drug-Gene interaction
view
Related drugs: 12 records
Drug name Interaction type Source PMID View
anacetrapib inhibitor TdgClinicalTrialChemblInteractionsTTD view
atorvastatin PharmGKB 161038961266360015856070 view
chembl1086624 TTD view
dalcetrapib inhibitor ChemblInteractionsTTD view
evacetrapib inhibitor ChemblInteractionsTTD view
fluvastatin PharmGKB 16002074 view
lovastatin PharmGKB 16103896 view
obicetrapib TTD view
pravastatin PharmGKB 189574721466099215044381942033915856070 view
simvastatin PharmGKB 1793108315856070 view
tamoxifen NCI 9751231 view
torcetrapib antagonist TdgClinicalTrial 1842246618221079 view
Related studies: 11 records
Molecular factor Omics type Application Objective MI type Reference
NM_000078.3:c.118+279G>A genomics myocardial infarction[diagnosis] myocardial infarction Eiriksdottir G et al. Atherosclerosis. 2001
NM_000078.3:c.-629C>A genomics myocardial infarction[diagnosis] myocardial infarction Tobin MD et al. Eur Heart J. 2004
NM_000078.3:c.1264G>A genomics myocardial infarction[diagnosis] myocardial infarction Isaacs A et al. Eur J Cardiovasc Prev Rehabil. 2007
NM_000078.3:c.1264G>A genomics high-density lipoprotein cholesterol[other] acute myocardial infarction Zende PD et al. J Clin Diagn Res. 2014
NM_000078.3:c.1264G>A genomics total cholesterol to high-density lipoprotein cholesterol ratio[other] acute myocardial infarction Zende PD et al. J Clin Diagn Res. 2014
NM_000078.3:c.[-2708G>A;-971A>G;-629A>C;118+279G>A;1264G>A] genomics acute myocardial infarction[diagnosis] acute myocardial infarction Meiner V et al. Ann Hum Genet. 2008
NM_000078.3:c.118+279G>A genomics myocardial infarction[diagnosis] myocardial infarction Goldenberg I et al. Ann Noninvasive Electrocardiol. 2007
cholesteryl ester transfer protein proteomics sudden cardiac death;recurrent myocardial infarction[prognosis (bad)] acute ST elevation myocardial infarction Carvalho LS et al. Atherosclerosis. 2014
cholesteryl ester transfer protein proteomics sudden cardiac death;recurrent myocardial infarction[prognosis (bad)] acute ST elevation myocardial infarction Carvalho LS et al. Atherosclerosis. 2014
NM_000078.3:c.118+279G>A genomics myocardial infarction[diagnosis] myocardial infarction Ridker PM et al. Circ Cardiovasc Genet. 2009
NM_000078.3:c.118+279G>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction Semaev S et al. Lipids Health Dis. 2019
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